HCID 178520865, compound → HCID 178519575, compound

Participants

Reaction Steps

A 13.55 g portion of manganese dioxide was added to 20 ml of dichloromethane solution containing 2.11 g of 1-(3,5-difluorophenyl)-2-(1,3-dihydro-2H-benzimidazol-2-ylidene)-3-[3-(hydroxymethyl)phenyl]propane-1,3-dione and stirred for 4.5 hours. After celite filtration and concentration, the thus formed residue was crystallized from hexane-ethyl acetate to obtain 1.09 g (52%) of 3-[3-(3,5-difluorophenyl)-2-(1,3-dihydro-2H-benzimidazol-2-ylidene)-3-oxopropanoyl]benzaldehyde (Reference Example 10-1). FA: 405

Provenance & Evidence