HuagongsheHuagongshe Chemistry Print Report · For research reference only
Adipic Acid → HCID 178484387, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Adipic Acid | HCID 196 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Metformin Hydrochloride | HCID 14219 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178484387 | HCID 178484387 | 119.1% |
Reaction Steps
10.00 g of metformin hydrochloride, 2.40 g of sodium hydroxide and 2.20 g of adipic acid were stirred in 150 ml of ethyl alcohol at 70° C., and then methylene chloride was added thereto. Then, the produced inorganic salt was filtered, and ethyl acetate was added to the filtrate. The produced crystal was filtered and dried in hot air, thus obtaining 4.90 g (yield: 80.5%) of metformin adipate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076377B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-6a57b952a08b47e2ab3e40695d305e26 |
| Source note | uspto-grants-2011_12 |