Acetone → HCID 178484389, compound

HRID 658133Notes

Reaction equation

HRID 658133 reaction equation
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[OH-].[Na+].[C:13]([OH:21])(=[O:20])[CH:14]([CH2:16][C:17]([OH:19])=[O:18])[OH:15].CC(C)=O>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:13]([O-:21])(=[O:20])[CH:14]([CH2:16][C:17]([O-:19])=[O:18])[OH:15]

Participants

6

Reactant 4

HCID 180AcetoneHCID 525Malic AcidHCID 14219Metformin HydrochlorideHCID 14798Sodium Hydroxide

Product 1

HCID 178484389HCID 178484389, compoundYield 67.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

20 g (2 molar equivalents) of metformin hydrochloride, 4.83 g (2 molar equivalents) of sodium hydroxide and 8.09 g (1 molar equivalent) of malic acid were stirred in 90 ml of water at 100° C., and acetone was added dropwise thereto at room temperature. Then, the produced crystal was stirred at room temperature for 1 hour, filtered and dried in hot air, thus obtaining 10.69 g (yield: 45.1%) of metformin malate.

Workup

  1. customat room temperature
  2. filtrationfiltered
  3. customdried in hot air

Sources & evidence

ORD record
ord-348ffdd65e474f4984482a151e7333c4
Source dataset
uspto-grants-2011_12
Patent number
US08076377B2

Reaction notes

Loading…