HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Thioglycolate → Methyl 7-(trifluoromethyl)-1-benzothiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Thioglycolate | HCID 16907 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Fluoro-3-(trifluoromethyl)benzaldehyde | HCID 517978 | — |
| Product | Methyl 7-(trifluoromethyl)-1-benzothiophene-2-carboxylate | HCID 18526203 | — |
Reaction Steps
Using 5.0 g (26.0 mmol) of 2-fluoro-3-trifluoromethylbenzaldehyde, 1.56 g (39.0 mmol) of sodium hydride (60% pure) and 3.0 g (28.6 mmol) of methyl mercaptoacetate, 5.4 g (79.7% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076355B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-a4799d6403974facbafb780c86e94d1e |
| Source note | uspto-grants-2011_12 |