HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Thioglycolate → 5-Trifluoromethyl-benzo[b]thiophene-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Thioglycolate | HCID 16907 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Fluoro-5-(trifluoromethyl)benzaldehyde | HCID 2734904 | — |
| Product | 5-Trifluoromethyl-benzo[b]thiophene-2-carboxylic acid methyl ester | HCID 1477956 | — |
Reaction Steps
Using 4.28 g (22.3 mmol) of 2-fluoro-5-trifluoromethylbenzaldehyde, 1.34 g (33.4 mmol) of sodium hydride (60% pure) and 2.6 g (24.5 mmol) of methyl mercaptoacetate, 4.93 g (80.0% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076355B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-957c2736ed1b4b33b685a55e2148c79e |
| Source note | uspto-grants-2011_12 |