HCID 15781018, compound → HCID 178425999, compound

Participants

Reaction Steps

1.90 g (10.09 mmol) of 2-phenyl-4-fluorophenol was dissolved in 80 ml of diethylether, and 4.8 ml of butyl lithium (2.5 M hexane solution) was slowly added dropwise thereto at 0° C. The mixture was allowed to react at room temperature for 5 hours, and then a solution of trichloro(pentamethylcyclopentadienyl)titanium (IV) (1.64 g, 5.5 mmol) in 10 ml of diethyl ether was slowly added dropwise thereto at −78° C. The reaction product was stirred at room temperature for 12 hours and filtered, and then volatile materials were removed therefrom. The residue was recrystallized from a mixed solvent of toluene/hexane at −35° C., thus obtaining 2.54 g of a orange-colored solid.

Provenance & Evidence