HCID 68973104, compound → HCID 86625978, compound

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Reaction Steps

N-{2-Oxo-1-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-1,2-dihydro-pyrimidin-4-yl}-acetamide (H) (0.44 g, 1.3 mmol) was dissolved in a solution of ammonia in MeOH (7 N) (50 ml). The mixture was stirred at room temperature for 16 h. After completion of the reaction the solvent was evaporated under reduced pressure and the crude material was purified over flash silica gel chromatography (CHCl3/MeOH, 10:1) to give compound 4-Amino-1-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-1H-pyrimidin-2-one (I) as a semi-solid (0.25 g, 65%).

Provenance & Evidence