HCID 86623301, compound → HCID 66776187, compound

HRID 658327Notes

Reaction equation

HRID 658327 reaction equation
[C:1]([CH2:3][CH2:4][N:5]([CH2:10][CH2:11][CH2:12][CH:13]1[O:18][CH2:17][C:16]2([CH2:23][O:22][CH:21]([CH2:24][CH2:25][CH2:26][N:27]([CH2:32][CH2:33][C:34]#[N:35])[CH2:28][CH2:29][C:30]#[N:31])[O:20][CH2:19]2)[CH2:15][O:14]1)[CH2:6][CH2:7][C:8]#[N:9])#[N:2].[H][H]>O1CCOCC1>[NH2:2][CH2:1][CH2:3][CH2:4][N:5]([CH2:10][CH2:11][CH2:12][CH:13]1[O:18][CH2:17][C:16]2([CH2:23][O:22][CH:21]([CH2:24][CH2:25][CH2:26][N:27]([CH2:28][CH2:29][CH2:30][NH2:31])[CH2:32][CH2:33][CH2:34][NH2:35])[O:20][CH2:19]2)[CH2:15][O:14]1)[CH2:6][CH2:7][CH2:8][NH2:9]

Participants

4

Reactant 2

HCID 86623301HCID 86623301, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66776187HCID 66776187, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5.00 g of N,N,N′,N′-tetrakis(2-cyanoethyl)-3,9-bis(aminopropyl)-2,4,8,10-tetraoxaspiro[5.5]undecane, 0.50 g of Raney Co and 50 mL of 1,4-dioxane were charged in an autoclave and a hydrogenation reaction was carried out at an initial hydrogen pressure of 8.0 MPa at 180° C. for 2 hours. After the catalyst was removed by filtration, the obtained filtrate was concentrated to dryness to give 5.01 g of the title compound as a pale red oil.

Workup

  1. customa hydrogenation reaction
  2. customAfter the catalyst was removed by filtration
  3. concentrationthe obtained filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-84bf2caec52544a08ed0d825e6abba54
Source dataset
uspto-grants-2011_12
Patent number
US08076478B2

Reaction notes

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