HCID 12403257, compound → HCID 12403258, compound

HRID 658331Notes

Reaction equation

HRID 658331 reaction equation
[C:1]([CH2:3][CH2:4][N:5]([CH2:10][CH2:11][CH2:12][N:13]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:14][CH2:15][CH2:16][N:17]([CH2:22][CH2:23][C:24]#[N:25])[CH2:18][CH2:19][C:20]#[N:21])[CH2:6][CH2:7][C:8]#[N:9])#[N:2].[H][H]>O1CCOCC1>[NH2:21][CH2:20][CH2:19][CH2:18][N:17]([CH2:16][CH2:15][CH2:14][N:13]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:12][CH2:11][CH2:10][N:5]([CH2:6][CH2:7][CH2:8][NH2:9])[CH2:4][CH2:3][CH2:1][NH2:2])[CH2:22][CH2:23][CH2:24][NH2:25]

Participants

4

Reactant 2

HCID 12403257HCID 12403257, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12403258HCID 12403258, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

6.50 g of N,N-bis(3-(N,N-bis(2-cyanoethyl)amino)propyl)benzylamine, 0.65 g of Raney Co and 100 mL of 1,4-dioxane were charged in an autoclave and a hydrogenation reaction was carried out at an initial hydrogen pressure of 9.0 MPa at 180° C. for 2 hours. After the catalyst was removed by filtration, the obtained filtrate was concentrated to dryness to give 6.16 g of the title compound as a pale yellow oil.

Workup

  1. customa hydrogenation reaction
  2. customAfter the catalyst was removed by filtration
  3. concentrationthe obtained filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-1af1576068644447b7aa5d8104849d5c
Source dataset
uspto-grants-2011_12
Patent number
US08076478B2

Reaction notes

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