HCID 3043620, compound → HCID 66745105, compound

HRID 658346Notes

Reaction equation

[NH2:1][C:2]([CH3:14])([CH3:13])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH3:12])[CH3:11])=[CH:6][CH:5]=1.[C:15]([O:19][C:20]1[CH:21]=[C:22]([C@H:33]([OH:40])[CH2:34]OS(C)(=O)=O)[C:23]2[S:27][C:26]([O:28][CH:29]([CH3:31])[CH3:30])=[N:25][C:24]=2[CH:32]=1)([CH3:18])([CH3:17])[CH3:16]>C1(C)C=CC=CC=1>[C:15]([O:19][C:20]1[CH:21]=[C:22]([C@H:33]([OH:40])[CH2:34][NH:1][C:2]([CH3:14])([CH3:13])[CH2:3][C:4]2[CH:9]=[CH:8][C:7]([N:10]([CH3:11])[CH3:12])=[CH:6][CH:5]=2)[C:23]2[S:27][C:26]([O:28][CH:29]([CH3:30])[CH3:31])=[N:25][C:24]=2[CH:32]=1)([CH3:16])([CH3:18])[CH3:17]

Participants

Conditions

Temperature: 80 °C

Procedure

[4-(2-Amino-2-methyl-propyl)-phenyl]-dimethyl-amine (210 mg) and Methanesulfonic acid (S)-2-(5-tert-butoxy-2-isopropoxy-benzothiazol-7-yl)-2-hydroxy-ethyl ester (120 mg) are dissolved in toluene (2 ml). The reaction mixture is heated to 80° C. for 20 hours. The solvent is removed by vacuo to give (S)-1-(5-tert-Butoxy-2-isopropoxy-benzothiazol-7-yl)-2-[2-(4-dimethylamino-phenyl)-1,1-dimethyl-ethylamino]-ethanol. MS (ES+) m/e. 500

Workup

customThe solvent is removed by vacuo

Sources & evidence

ORD record: ord-0293fc1148144734ab2442d282150cdc
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08076489B2

Reaction notes

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