Citric Acid → HCID 86645107, compound

Participants

Reaction Steps

Ethyl malonyl chloride (5.0 g, 33 mmol) was added to a mixed solution of N,N-dimethylhydrazine (4.0 g, 67 mmol), triethylamine (6.7 g, 66 mmol) and acetonitrile (30 mL) at 10° C. or below. The mixture was stirred overnight at room temperature. The reaction mixture was added with an aqueous solution of citric acid, and extracted with chloroform. The organic layer was washed with water, dried, and concentrated, to obtain 4.6 g of a desired product (yield: 79%).

Provenance & Evidence