Lithium hydroxide, monohydrate → HCID 68492502, compound

Participants

Reaction Steps

Methyl 1,2-dihydro-1-methyl-6-methylthio-2-oxopyridine-3-carboxylate (2.1 g, 9.8 mmol) and lithium hydroxide monohydrate (0.50 g, 12 mmol) were dissolved in a mixed solvent of THF (30 mL) and water (2 mL), and stirred for a day at room temperature. The reaction mixture was concentrated under reduced pressure. To thus obtained residue, a mixed solution of aqueous saturated sodium bicarbonate and ethyl acetate was added, and then liquid separation and extraction were subjected. The obtained liquid layer was added with diluted hydrochloric acid to give a pH of 3 to 4, and extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure, to obtain 1.6 g of a desired product (yield: 82%).

Provenance & Evidence