1-(1H-imidazole-1-carboximidoyl)-1H-imidazole → HCID 17747573, compound

HRID 658363Notes

Reaction equation

HRID 658363 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:19]=[N:18][CH:17]=[CH:16][C:11]=1[C:12]([NH:14][NH2:15])=[O:13].[N:20]1(C(=N)N2C=CN=C2)C=CN=[CH:21]1>CS(C)=O>[NH2:20][C:21]1[O:13][C:12]([C:11]2[CH:16]=[CH:17][N:18]=[CH:19][C:10]=2[NH:9][C:3]2[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=2[F:1])=[N:14][N:15]=1

Participants

4

Reactant 2

HCID 113556541-(1H-imidazole-1-carboximidoyl)-1H-imidazoleHCID 115888023-[(2-Fluoro-4-iodophenyl)amino]isonicotinohydrazide

Product 1

HCID 17747573HCID 17747573, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a solution of 3-(2-Fluoro-4-iodo-phenylamino)-isonicotinic acid hydrazide (1 g, 2.68 mmol) in DMSO (6 mL) were added 1,1-di-1H-imidazol-1-yl-methyleneamine (864 mg, 5.36 mmol). The reaction mixture was stirred at RT for 18 h. Quenching of the reaction by adding water (60 mL). A solid precipitated out. The solid was filtered, washed with water and cold methanol. Yield: white solid 1.0 g. LC-MS (Method A) [4.66 min; 398(M+1)].

Workup

  1. customQuenching of the reaction
  2. additionby adding water (60 mL)
  3. customA solid precipitated out
  4. filtrationThe solid was filtered
  5. washwashed with water and cold methanol
  6. customLC-MS (Method A) [4.66 min; 398(M+1)]

Sources & evidence

ORD record
ord-7a28ea4cd7e24d478c5dcd4e04b62212
Source dataset
uspto-grants-2011_12
Patent number
US08076486B2

Reaction notes

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