反应详情

To a solution of 3-(2-Fluoro-4-iodo-phenylamino)-isonicotinic acid hydrazide (1 g, 2.68 mmol) in DMSO (6 mL) were added 1,1-di-1H-imidazol-1-yl-methyleneamine (864 mg, 5.36 mmol). The reaction mixture was stirred at RT for 18 h. Quenching of the reaction by adding water (60 mL). A solid precipitated out. The solid was filtered, washed with water and cold methanol. Yield: white solid 1.0 g. LC-MS (Method A) [4.66 min; 398(M+1)].

1. customQuenching of the reaction
2. additionby adding water (60 mL)
3. customA solid precipitated out
4. filtrationThe solid was filtered
5. washwashed with water and cold methanol
6. customLC-MS (Method A) [4.66 min; 398(M+1)]