Trifluoroacetic acid → HCID 59026820, compound

Participants

Reaction Steps

(4-{5-[(2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-amino]-[1,3,4]oxadiazol-2-yl}-pyridin-3-yl)-(2-fluoro-4-iodo-phenyl)-amine (100 mg, 0.2 mmol) was dissolved in dichloromethane (5 mL) and TFA (3 mL) was added. The reaction mixture was stirred at RT for 4 hrs. The solvent was evaporated, and the residue was dissolved in Ethyl acetate, and washed with 1N aqueous NaOH. After solvent evaporation a residue was collected and dissolved in methanol. The product crystallized out the methanolic solution and filtered (63 mg). LC/MS (Method A) [6.61 min; 472(M+1)].

Provenance & Evidence