Trichloroacetonitrile → HCID 59026763, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(2-Fluoro-4-iodo-phenylamino)-isonicotinic acid N′-acetyl-hydrazide (400 mg; 0.93 mmol; 1 eq) in DMA (5 mL), PS-Triphenyl-phosphine (1.22 g; 4.66 mmol; 5 eq), Trichloro-acetonitrile (269 mg; 1.86 mmol; 2 eq) and DIEPA (0.49 mL; 2.8 mmol; 3 eq) were added. The reaction mixture was stirred at 100° C. for 4 hrs. The mixture was filtered and the solution was subjected to preparative HPLC to afford the product (98 mg). LC/MS (Method A) [5.03 min; 412(M+1)]

Provenance & Evidence