Trichloroacetonitrile → HCID 59026804, compound

Participants

Reaction Conditions

Reaction Steps

3-(2-Fluoro-4-iodo-phenylamino)-isonicotinic acid N′-(3-dimethylamino-propionyl)-hydrazide (130 mg, 0.27 mmol) was dissolved in DMA (2 mL), and then PS-Triphenyl-phosphane (420 mg, 1.6 mmol, 6 eq), Trichloro-acetonitrile (77 mg, 0.53 mmol, 2 eq) and DIEPA (0.19 mL, 1.07 mmol, 4 eq) were added. The reaction mixture was stirred at 100° C. overnight, and then filtered. The filtrate was directly subjected to preparative HPLC to afford 32 mg of the desired product. LC/MS (Method A) [3.63 min; 467(M+1)]

Provenance & Evidence