Water → HCID 178470462, compound

Participants

Reaction Steps

Amino-{[3-(2-fluoro-4-iodo-phenylamino)-pyridine-4-carbonyl]-hydrazono}-acetic acid ethyl ester (1.6 g, 3.4 mmo) in pyridine (10 mL) was stirred at 140° C. for 3 hrs. Cooled, poured into water, Extracted with EtOAc, Combined the organic layer, and washed with Brine, dried over MgSO4, filtered, removed off solvent, got crude product, which was subjected to silica gel column (Hex:EtOAc=1:1). Collected final product 1.02 g. [5.23 min, 454 (M+1)]

Provenance & Evidence