Pyridine → HCID 59026806, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of {N′-[3-(2-Fluoro-4-iodo-phenylamino)-pyridine-4-carbonyl]-hydrazino}-oxo-acetic acid ethyl ester (1.27 g, 2.69 mmol, 1.0 eq.) in DCM (20 mL) containing pyridine (0.55 g, 6.99 mmol. 2.66 eq.) thionyl dichloride (0.26 mL, 3.5 mmol; 1.30 eq) was added at 0° C. The reaction mixture were stirred at 0° C. for 2 hrs. The solvent was evaporated, toluene was added and the reaction mixture was stirred at 110° C. for 6 hrs. Removal of the solvent resulted in a residue that was subjected to silica gel column chromatography (EtOAc:Hex=1:2) to afford the desired product (0.50 g). [5.32 min; 455 (M+1)]

Provenance & Evidence