Hydrochloric Acid → HCID 59026779, compound

Participants

Reaction Steps

To a solution of 5-[3-(2-Fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester (200 mg, 0.44 mmol) in THF-H2O (1:1)(5 mL) LiOH (32 mg, 1.32 mmol) was added. The reaction mixture was stirred for 2 hrs and then the pH was adjusted to 5 with 1N HCl. Upon dilution with water a solid precipitated. Filtration afforded the desired product (89 mg). LC/MS (Method A) [0.48 min; 383(M+1)]

Provenance & Evidence