Ammonium Acetate → HCID 59026812, compound

Participants

Reaction Steps

To a solution of {5-[3-(2-Fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid (75 mg, 0.16 mmol, 1 eq) in DMF CDI (35 mg, 0.21 mmol, 1.3 eq) was added. The reaction mixture was stirred at RT under argon for 3 hrs and then amoniumacetate (30 mg, 0.41 mmol, 2.5 eq) was added. The mixture was stirred for another 2 hrs. The resulting mixture was directly purified by preparative HPLC to afford the desired product (35 mg). LC/MS (Method A) [4.57 min; 455(M+1)]

Provenance & Evidence