反应详情

To a solution of {5-[3-(2-Fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid (75 mg, 0.16 mmol, 1 eq) in DMF CDI (35 mg, 0.21 mmol, 1.3 eq) was added. The reaction mixture was stirred at RT under argon for 3 hrs. Then diisopropanlethylamine (352 mg, 0.41 mmol, 2.5 eq), and dimethylamine hydrichloride (40 mg, 0.41 mmol, 2.5 eq) was added and the mixture was stirred for another 2 hrs. It was then directly purified by reverse phase preparative HPLC to give the desired product (35 mg). LC/MS (Method A) [4.87 min; 483 (M+1)]

1. stirringthe mixture was stirred for another 2 hrs
2. customIt was then directly purified by reverse phase preparative HPLC