1,1'-Carbonyldiimidazole → HCID 59026765, compound

Participants

Reaction Steps

To a solution of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (360 mg; 1.01 mmol) was added 1,1′-carbonylbis(1H-imidazole) (196 mg; 1.21 mmol). The mixture was stirred overnight. The dark yellow colored solution was treated with thiosemicarbazide (110 mg mg; 1.21 mmol). The reaction mixture was stirred at room temperature overnight. Water (10 mL) was added, and extracted with ethyl acetate. Concentrated and purified on Flashmaster to obtain 2-{3-[(2-fluoro-4-iodophenyl)amino]isonicotinoyl}hydrazine carbothioamide. (300 mg, 69%) MS m/z: 432 M+1

Provenance & Evidence