Triethylamine → HCID 59026785, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-{3-[(2-fluoro-4-iodophenyl)amino]isonicotinoyl}hydrazine carbothioamide (220 mg; 0.51 mmol) in DMF (5.00 mL) were added resin bound triphenylphosphine (401 mg; 1.53 mmol), carbon tetrabromide tetrabromomethane (508 mg; 1.53 mmol), and triethyl amine (180 mg; 1.53 mmol). The mixture was heated at 50° C. for 5 h. Filtered and purified on Agilent Prep. HPLC system to get 10 mg of [4-(5-Amino-[1,3,4]thiadiazol-2-yl)-pyridin-3-yl]-(2-fluoro-4-iodo-phenyl)-amine. MS m/z: 414 M+1

Provenance & Evidence