Pyridine → HCID 59026801, compound

Participants

Reaction Steps

Pyridine (28 μL, 0.35 mmol) and trifluoroacetic anhydride (27 μL, 0.19 mmol) were added to a solution of 3-(2-fluoro-4-iodo-phenylamino)-5-(2-fluoro-phenyl)-isonicotinamide (78 mg, 0.17 mmol) in dioxane (2 mL) at 0° C. The resulting solution was stirred for 3 h at room temperature. The reaction was quenched with 2M NaOH and stirred for 10 minutes. The reaction solution was diluted with EtOAc and satd. NH4Cl, and filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated to provide a precipitate. The precipitate was washed with MeOH and dried under vacuum to afford the desired product (60 mg, 80%). LC-MS (M+H=434, obsd.=434).

Provenance & Evidence