Sodium Hydroxide → HCID 178505938, compound

Participants

Reaction Conditions

Reaction Steps

NaOH (50 μL, 2.0 M in H2O, 0.09 mmol) was added to a solution of (2-fluoro-4-iodo-phenyl)-[5-(2-fluoro-phenyl)-4-(5-trimethylsilanyl-1H-[1,2,3]triazol-4-yl)-pyridin-3-yl]-amine (10 mg, 0.02 mmol) in MeOH (1 mL), and stirred overnight at 50° C. The reaction was quenched with satd. NH4Cl, diluted with EtOAc, and filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was purified via Biotage eluting with a gradient of 0 to 75% EtOAc in hexanes to afford the desired product (6 mg, 69%) as a yellow solid. LC-MS (M+H=476, obsd.=476). 1H NMR: δ 8.51 (s, 1H), 8.19 (s, 1H), 7.62 (dd, 1H), 7.44 (m, 1H), 7.38 (m, 2H), 7.28 (m, 2H), 7.19 (t, 1H), 6.99 (s, 1H).

Provenance & Evidence