Sodium Hydroxide → HCID 178505936, compound

Participants

Reaction Steps

N-(2-fluoro-4-iodophenyl)-4-[5-(trimethylsilyl)-1H-1,2,3-triazol-4-yl]pyridin-3-amine (20 mg, 0.044 mmol) was added into a solution of NaOH (3.5 mg, 0.088 mmol) in THF (0.5 mL) for 5 days. The mixture was diluted with MeOH and neutralized to pH7 with acidic resin (Dowex). After filtration and the filtrate was concentrated to give pure product (11.5 mg, 69%). LC/MS [Method A: rt: 0.40 min; m/z: 381 (M+1)].

Provenance & Evidence