反应详情

It will be appreciated by those skilled in the art that the sequence of steps in the processes described above may be performed in a different order for example 3-hydroxy-5-[(1S)-2-methoxy-1-methylethoxy]benzoic acid may be reacted with 5-methylpyrazine-2-amine to give (S)-3-hydroxy-5-(1-methoxypropan-2-yloxy)-N-(5-methylpyrazin-2-yl)benzamide, for example as described below. The conversion of (S)-3-hydroxy-5-(1-methoxypropan-2-yloxy)-N-(5-methylpyrazin-2-yl)benzamide into 3-{[5-(azetidin-1-ylcarbonyl)pyrazin-2-yl]oxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(5-methylpyrazin-2-yl)benzamide may be carried out as described in WO2007/007041.