HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitroxoline → 5-Amino-8-hydroxyquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitroxoline | HCID 19910 | — |
| Reactant | 4-Amino-3-fluorophenol | HCID 2735919 | — |
| Product | 5-Amino-8-hydroxyquinoline | HCID 416002 | 57% |
Reaction Steps
This compound was prepared from 8-hydroxy-5-nitroquinoline (5.0 g, 26.3 mmol) in the manner described for 4-amino-3-fluorophenol, affording 2.4 g (51.3%) of 5-amino-8-hydroxyquinoline. TLC (5% MeOH/DCM), Rf=0.52.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076488B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-1507a0dd847d4b5abdeed4758b6e6078 |
| Source note | uspto-grants-2011_12 |