HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluoro-5-nitrophenol → 2-Bromo-4-fluoro-3-nitrophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluoro-5-nitrophenol | HCID 10921024 | — |
| Reactant | Ethyl-2-bromo-4-fluorophenoxycarboxlate | HCID 131729328 | — |
| Product | 2-Bromo-4-fluoro-3-nitrophenol | HCID 53923881 | 87.5% |
Reaction Steps
This compound was prepared from ethyl-2-bromo-4-fluorophenoxycarboxlate (4.0 g, 15.2 mmol) in the manner described for 2,4-difluoro-5-nitrophenol, affording 3.14 g (87.5%) of 2-bromo-4-fluoro-3-nitrophenol as a yellow solid. 1H-NMR (DMSO-d6) δ 11.19 (s, 1H), 7.89 (d, J=8.4 Hz, 1H), 7.57 (d, J=5.1 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076488B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-c0599f1286d145eab4c0420358451e7e |
| Source note | uspto-grants-2011_12 |