4-Amino-3-fluorophenol → HCID 19986948, compound

HRID 658458Notes

Reaction equation

HRID 658458 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([F:11])[C:3]=1[OH:12].NC1C=CC(O)=CC=1F>>[NH2:8][C:6]1[CH:5]=[C:4]([F:11])[C:3]([OH:12])=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 27359194-Amino-3-fluorophenolHCID 59987459757251-37-9

Product 1

HCID 19986948HCID 19986948, compoundYield 40%

Procedure

This compound was prepared from 2-chloro-6-fluoro-4-nitrophenol (1.3 g, 6.79 mmol) in the manner described for 4-amino-3-fluorophenol, affording 0.34 g (40%) of 4-amino-2-chloro-6-fluorophenol. 1H-NMR (DMSO-d6) δ 4.99 (s, 2H), 6.29-6.36 (m, 2H), 8.85 (s, 1H).

Sources & evidence

ORD record
ord-8591feb903e143d8a637d775e505f94b
Source dataset
uspto-grants-2011_12
Patent number
US08076488B2

Reaction notes

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