HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3-Trifluoro-4-nitrobenzene → 4-Amino-2,3-difluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3-Trifluoro-4-nitrobenzene | HCID 69871 | — |
| Reactant | 4-Amino-3,5-difluorophenol | HCID 2778761 | — |
| Product | 4-Amino-2,3-difluorophenol | HCID 2778766 | 84% |
Reaction Steps
This compound was prepared from 1,2,3-trifluoro-4-nitrobenzene (5.0 g, 28 mmol) in the manner described for 4-amino-3,5-difluorophenol, affording 0.60 g (84%) of 4-amino-2,3-difluorophenol. 1H-NMR (DMSO-d6) δ 9.19 (s, 1H), 6.59 to 6.53 (m, 1H), 6.48 to 6.41 (m, 1H), 4.85 (s, 2H); TLC (12% DCM/Hex), Rf=0.08.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076488B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-3a5793a63d1345cba0beb0e0311fd238 |
| Source note | uspto-grants-2011_12 |