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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 658469Generated: October 25, 2026

4-Aminophenol → 4-(4-amino-3-methylphenoxy)-N-methylpyridine-2-carboxamide

https://huagongshe.com/reaction/658469

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-AminophenolHCID 403—
Reactant4-(4-Aminophenoxy)-N-methylpicolinamideHCID 16655129—
Product4-(4-amino-3-methylphenoxy)-N-methylpyridine-2-carboxamideHCID 23137246—

Reaction Steps

The title compound was prepared in the same manner described for 4-(4-aminophenoxy)pyridine-2-carboxylic acid methylamide, substituting 4-amino-3-methylphenol for 4-aminophenol. 1H-NMR (acetone-d6) δ 8.39 (d, J=5.7 Hz, 1H), 8.29 (br s, 1H), 7.51 (dd, J=2.7, 0.6 Hz, 1H), 6.98 (dd, J=5.7, 2.4 Hz, 1H), 6.82 (br s, 1H), 6.77 to 6.76 (m, 2H), 4.56 (br s, 2H), 2.92 (d, J=5.1 Hz, 3H), 2.16 (d, J=1.0 Hz, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08076488B2
Source datasetuspto-grants-2011_12
ORD IDord-3f2fc586560b4bf9998fe734e2837a82
Source noteuspto-grants-2011_12