4-Chloro-N-methylpicolinamide → 4-(4-Aminophenoxy)pyridine-2-carboxylic acid methylcarbamoylmethylamide
Reaction equation
[NH2:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][N:10]=[C:9]([C:13]([NH2:15])=[O:14])[CH:8]=2)=[CH:4][CH:3]=1.ClC1C=CN=[C:21]([C:25]([NH:27][CH3:28])=[O:26])C=1>>[CH3:28][NH:27][C:25]([CH2:21][NH:15][C:13]([C:9]1[CH:8]=[C:7]([O:6][C:5]2[CH:16]=[CH:17][C:2]([NH2:1])=[CH:3][CH:4]=2)[CH:12]=[CH:11][N:10]=1)=[O:14])=[O:26]Participants
3
Procedure
The title compound was prepared in the same manner described for 4-(4-aminophenoxy)-pyridine-2-carboxamide, substituting of 4-chloropyridine-2-carboxylic acid N-methylcarbamoylmethylamide for 4-chloro-N-methyl-pyridine-2-carboxamide.
Sources & evidence
- ORD record
- ord-93816b7d2222471a815a8acbfacb880f
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08076488B2
Reaction notes
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