1H-Imidazole-1-propanamine → HCID 59987456, compound

HRID 658500Notes

Reaction equation

HRID 658500 reaction equation
N1(CC[CH2:8][NH:9][C:10]([C:12]2[CH:17]=[C:16]([O:18][C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]4[CH:42]=[CH:41][C:32]5[O:33][C:34]([F:40])([F:39])[O:35][C:36]([F:38])([F:37])[C:31]=5[CH:30]=4)=[O:27])=[CH:21][CH:20]=3)[CH:15]=[CH:14][N:13]=2)=[O:11])C=CN=C1.NC[CH2:45][CH2:46][N:47]1[CH:51]=[CH:50]N=[CH:48]1>>[N:47]1([CH2:48][CH2:8][NH:9][C:10]([C:12]2[CH:17]=[C:16]([O:18][C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]4[CH:42]=[CH:41][C:32]5[O:33][C:34]([F:39])([F:40])[O:35][C:36]([F:37])([F:38])[C:31]=5[CH:30]=4)=[O:27])=[CH:21][CH:20]=3)[CH:15]=[CH:14][N:13]=2)=[O:11])[CH2:46][CH2:45][CH2:50][CH2:51]1

Participants

3

Reactant 2

HCID 787361H-Imidazole-1-propanamineHCID 59987457HCID 59987457, compound

Product 1

HCID 59987456HCID 59987456, compound

Procedure

The title compound was prepared in the same manner described for N-[3-(1H-imidazol-1-yl)propyl]-4-[4-({[(2,2,4,4-tetrafluoro-4H-1,3-benzodioxin-6-yl)amino]carbonyl}-amino)phenoxy]pyridine-2-carboxamide, substituting 1-(2-aminoethyl)pyrrolidone for 1-(3-aminopropyl)imidazole. 1H-NMR (MeOH-d4) δ 8.45 (d, 1H), 8.00 (d, 1H), 7.65 (dd, 1H), 7.56 (m, 3H), 7.22 (d, 1H), 7.10 (m, 2H), 7.04 (dd, 1H), 3.57 (t, 2H), 2.77 (t, 2H), 2.67 (m, 4H), 1.83 (m, 4H); MS LC-MS [M+H]+=576.2, RT=3.16 min.

Sources & evidence

ORD record
ord-03ee754fe867464f8ded74568e9e541b
Source dataset
uspto-grants-2011_12
Patent number
US08076488B2

Reaction notes

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