Dimethyl Sulfate → 4',5'-Dihydro-8-methoxypsoralen

HRID 65852Notes

Reaction equation

HRID 65852 reaction equation
[CH2:1]1[C:5]2[CH:6]=[C:7]3[C:13](=[C:14]([OH:15])[C:4]=2[O:3][CH2:2]1)[O:12][C:10](=[O:11])[CH:9]=[CH:8]3.S(OC)(O[CH3:20])(=O)=O>>[CH3:20][O:15][C:14]1[C:4]2[O:3][CH2:2][CH2:1][C:5]=2[CH:6]=[C:7]2[CH:8]=[CH:9][C:10]([O:12][C:13]=12)=[O:11]

Participants

3

Reactant 2

HCID 6497Dimethyl SulfateHCID 1066482,3-Dihydro-9-hydroxy-7H-furo[3,2-g][1]benzopyran-7-one

Product 1

HCID 774094',5'-Dihydro-8-methoxypsoralen

Procedure

The process of claim 1, in which the 2,3-dihydroxanthotoxol of step 4 is methylated with dimethyl sulfate to form 2,3-dihydroxanthotoxin.

Sources & evidence

ORD record
ord-72c3766a944540d9b6a4dccd7f0c1ed2
Source dataset
uspto-grants-1978_12
Patent number
US04129575

Reaction notes

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