HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59804554, compound → [(R)-3-(2-tert-Butylcarbamoyl-5-chloro-phenyl)-2-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59804554 | HCID 59804554 | — |
| Reactant | [(R)-1-(Methoxy-methyl-carbamoyl)-2-(2,4,5-trifluoro-phenyl)-ethyl]-carbamic acid tert-butyl ester | HCID 59804556 | — |
| Product | [(R)-3-(2-tert-Butylcarbamoyl-5-chloro-phenyl)-2-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester | HCID 69108970 | — |
Reaction Steps
Using general procedure 2 with [(R)-1-(methoxy-methyl-carbamoyl)-2-(2,4,5-trifluoro-phenyl)-ethyl]-carbamic acid tert-butyl ester (1.4 g, 3.4 mmol) and N-tert-butyl-4-chloro-2-methyl-benzamide (2.3 g, 10 mmol) followed by purification by silica gel flash column chromatography gives the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076514B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-6d79c700cedb4909ba4078d49fe24699 |
| Source note | uspto-grants-2011_12 |