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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 658539Generated: November 4, 2026

HCID 59804554, compound → [(R)-3-(2-tert-Butylcarbamoyl-5-chloro-phenyl)-2-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/658539

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 59804554HCID 59804554—
Reactant[(R)-1-(Methoxy-methyl-carbamoyl)-2-(2,4,5-trifluoro-phenyl)-ethyl]-carbamic acid tert-butyl esterHCID 59804556—
Product[(R)-3-(2-tert-Butylcarbamoyl-5-chloro-phenyl)-2-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl esterHCID 69108970—

Reaction Steps

Using general procedure 2 with [(R)-1-(methoxy-methyl-carbamoyl)-2-(2,4,5-trifluoro-phenyl)-ethyl]-carbamic acid tert-butyl ester (1.4 g, 3.4 mmol) and N-tert-butyl-4-chloro-2-methyl-benzamide (2.3 g, 10 mmol) followed by purification by silica gel flash column chromatography gives the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08076514B2
Source datasetuspto-grants-2011_12
ORD IDord-6d79c700cedb4909ba4078d49fe24699
Source noteuspto-grants-2011_12