HCID 59799830, compound → HCID 69108671, compound

HRID 658541Notes

Reaction equation

HRID 658541 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]([C:18](=[O:23])N(OC)C)[CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[F:17])([CH3:4])([CH3:3])[CH3:2].[C:25]([NH:29][C:30](=[O:39])[C:31]1[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][C:32]=1[CH3:38])([CH3:28])([CH3:27])[CH3:26]>>[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[F:17])[C:18](=[O:23])[CH2:38][C:32]1[CH:33]=[C:34]([Cl:37])[CH:35]=[CH:36][C:31]=1[C:30](=[O:39])[NH:29][C:25]([CH3:27])([CH3:26])[CH3:28])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 59799830HCID 59799830, compoundHCID 59804554HCID 59804554, compound

Product 1

HCID 69108671HCID 69108671, compound

Procedure

Using general procedure 2 with [(R)-2-(2,5-Difluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester (2.5 g, 7.4 mmol) and N-tert-Butyl-4-chloro-2-methyl-benzamide (5.0 g, 22 mmol) followed by purification by silica gel flash column chromatography gives the title compound.

Workup

  1. customfollowed by purification by silica gel flash column chromatography

Sources & evidence

ORD record
ord-9ec744981e914401b0b9e7aa08e531a4
Source dataset
uspto-grants-2011_12
Patent number
US08076514B2

Reaction notes

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