N-tert-Butyl-2,6-dimethylbenzamide → [(R)-3-(2-tert-Butylcarbamoyl-3-methyl-phenyl)-1-(2-fluoro-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester
反応式
[C:1]([O:5][C:6](=[O:23])[NH:7][C@@H:8]([C:17](=[O:22])N(OC)C)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])([CH3:4])([CH3:3])[CH3:2].[C:24]([NH:28][C:29](=[O:38])[C:30]1[C:35]([CH3:36])=[CH:34][CH:33]=[CH:32][C:31]=1[CH3:37])([CH3:27])([CH3:26])[CH3:25]>>[C:1]([O:5][C:6](=[O:23])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])[C:17](=[O:22])[CH2:36][C:35]1[CH:34]=[CH:33][CH:32]=[C:31]([CH3:37])[C:30]=1[C:29](=[O:38])[NH:28][C:24]([CH3:26])([CH3:25])[CH3:27])([CH3:2])([CH3:3])[CH3:4]参加物
3
実験手順
Using general procedure 2 with [(R)-2-(2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester (2.65 g, 8.1 mmol) and N-tert-butyl-2,6-dimethyl-benzamide (5.0 g, 24 mmol), followed by purification by silica gel flash column chromatography gives the title compound.
後処理
- customfollowed by purification by silica gel flash column chromatography