[(R)-2-(2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester → [(R)-3-(2-tert-Butylcarbamoyl-3-chloro-phenyl)-1-(2-fluoro-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester

Participants

Reaction Steps

Using general procedure 2 with [(R)-2-(2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester (1.5 g, 4.6 mmol) and N-tert-butyl-2-chloro-6-methyl-benzamide (1.5 g, 4.6 mmol), followed by purification by silica gel flash column chromatography gives the title compound.

Provenance & Evidence