HCID 57419852, compound → HCID 57944916, compound

Participants

Role	Name	HCID	Charge
Reactant	HCID 57419852	HCID 57419852	—
Reactant	3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione	HCID 57422424	—
Product	HCID 57944916	HCID 57944916	22%

Reaction Steps

Prepared as in example 10-5 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 3-(bromomethyl)-1,5-dimethyl-1H-pyrazole. Yield: 22%. MS M+H calculated 384.1; found 384.1. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.3 uM

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08076491B2
Source dataset	uspto-grants-2011_12
ORD ID	ord-0d4a9b54b5004bebab4021c296a98fee
Source note	uspto-grants-2011_12