HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)benzonitrile → HCID 57422453, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| Reactant | 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione | HCID 57422424 | — |
| Product | HCID 57422453 | HCID 57422453 | 21% |
Reaction Steps
Prepared as in example 10-5 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 4-(bromomethyl)benzonitrile. Yield 21%. MS M+H calculated 391.1; found 391.2. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.05 uM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076491B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-baa31cb81ab34b65921652cae178cf82 |
| Source note | uspto-grants-2011_12 |