3-Methoxybenzylamine → HCID 57422469, compound

Participants

Reaction Steps

Prepared as in Example 10-48 from 3-(1-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-2,5-dioxoimidazolidin-4-yl)acetic acid (example 10-44) and (3-methoxyphenyl)methanamine. Yield: 50%. LC/MS; expected 453; found 453.1 The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 1.7 μM.

Provenance & Evidence