HuagongsheHuagongshe Chemistry Print Report · For research reference only
[6-(Bromomethyl)pyridin-2-yl]methanol → HCID 57422487, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [6-(Bromomethyl)pyridin-2-yl]methanol | HCID 10878213 | — |
| Reactant | 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione | HCID 57422424 | — |
| Product | HCID 57422487 | HCID 57422487 | 35% |
Reaction Steps
Prepared as in example 10-5 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione and 6-bromomethyl-2-pyridinemethanol. Yield: 35%. MS M+H calculated 397.2; found 397.2. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.72 μM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076491B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-36c0200cbc5b4e5cb64b550db8ea77d4 |
| Source note | uspto-grants-2011_12 |