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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 658764Generated: October 29, 2026

3-(t-Butyldimethylsilyloxy)benzaldehyde → Ethyl 1-(3-(tert-butyldimethylsilyloxy)benzylamino)cyclobutanecarboxylate

https://huagongshe.com/reaction/658764

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(t-Butyldimethylsilyloxy)benzaldehydeHCID 11207111—
ReactantEthyl 1-aminocyclobutane-1-carboxylate hydrochlorideHCID 16217503—
ProductEthyl 1-(3-(tert-butyldimethylsilyloxy)benzylamino)cyclobutanecarboxylateHCID 5952439077%

Reaction Steps

Prepared as in Example 12-1b from 3-(tert-butyldimethylsilyloxy)benzaldehyde (Example 12-1c) and ethyl 1-aminocyclobutanecarboxylate hydrochloride. Yield 77%, colorless liquid. MS 364 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08076491B2
Source datasetuspto-grants-2011_12
ORD IDord-54015eaefc7f4a47acd81cae07f9e6eb
Source noteuspto-grants-2011_12