3-(Chloromethyl)-1,5-dimethyl-1H-pyrazole → HCID 53373741, compound

HRID 658786Notes

Reaction equation

HRID 658786 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][N:8]2[CH:12]=[C:11]([N:13]3[C:17](=[O:18])[C:16]([CH3:20])([CH3:19])[NH:15][C:14]3=[O:21])[CH:10]=[N:9]2)=[C:5]([CH3:22])[O:4][N:3]=1.Cl[CH2:24][C:25]1[CH:29]=[C:28]([CH3:30])[N:27]([CH3:31])[N:26]=1>>[CH3:31][N:27]1[C:28]([CH3:30])=[CH:29][C:25]([CH2:24][N:15]2[C:16]([CH3:19])([CH3:20])[C:17](=[O:18])[N:13]([C:11]3[CH:10]=[N:9][N:8]([CH2:7][C:6]4[C:2]([CH3:1])=[N:3][O:4][C:5]=4[CH3:22])[CH:12]=3)[C:14]2=[O:21])=[N:26]1

Participants

3

Reactant 2

HCID 75374753-(Chloromethyl)-1,5-dimethyl-1H-pyrazoleHCID 595243883-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione

Product 1

HCID 53373741HCID 53373741, compound

Procedure

Prepared as in Example 12-16 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione (Example 12-16a) and 3-(chloromethyl)-1,5-dimethyl-1H-pyrazole. MS 412 (MH+). The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.16 μM.

Sources & evidence

ORD record
ord-0b4b96331a314644b3492c3a30dec197
Source dataset
uspto-grants-2011_12
Patent number
US08076491B2

Reaction notes

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