HCID 86635859, compound → HCID 86635858, compound

HRID 658848Notes

Reaction equation

HRID 658848 reaction equation
[OH:1][CH:2]([C:12]1[CH:13]=[C:14]([C:18]#[C:19][CH2:20][CH2:21][C:22]([N:24]([CH3:26])[CH3:25])=[O:23])[CH:15]=[CH:16][CH:17]=1)[CH2:3][CH2:4][NH:5][C:6](=[O:11])[C:7]([F:10])([F:9])[F:8]>CCO>[OH:1][CH:2]([C:12]1[CH:13]=[C:14]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]([N:24]([CH3:26])[CH3:25])=[O:23])[CH:15]=[CH:16][CH:17]=1)[CH2:3][CH2:4][NH:5][C:6](=[O:11])[C:7]([F:10])([F:9])[F:8]

Participants

3

Reactant 1

HCID 86635859HCID 86635859, compound

Product 1

HCID 86635858HCID 86635858, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reduction reaction of 5-(3-(1-hydroxy-3-(2,2,2-trifluoro acetamido) propyl)phenyl)-N,N-dimethylpent-4-ynamide in EtOH gave 5-(3-(1-hydroxy-3-(2,2,2-trifluoroacetamido)propyl)phenyl)-N,N-dimethylpentanamide as yellow oil. Yield (0.63 g, 99%): 1H NMR (400 MHz, CDCl3) δ 7.62 (bs, 1H), 7.24-7.28 (m, 1H), 7.19 (s, 1H), 7.12 (m, 2H), 4.85 (t, J=6.8 Hz, 1H), 3.57-3.65 (m, 1H), 3.35-3.44 (m, 1H), 2.99 (s, 3H), 2.92 (s, 3H), 2.65 (t, J=6.8 Hz, 2H), 2.29 (t, J=6.8 Hz, 2H), 1.98-2.03 (m, 2H), 1.62-1.68 (m, 4H).

Sources & evidence

ORD record
ord-e33c1dcf680848b39bce347966c78d74
Source dataset
uspto-grants-2011_12
Patent number
US08076516B2

Reaction notes

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