HCID 86635861, compound → HCID 86635860, compound

HRID 658850Notes

Reaction equation

HRID 658850 reaction equation
[OH:1][CH:2]([C:12]1[CH:13]=[C:14]([C:18]#[C:19][CH2:20][CH2:21][C:22]([NH:24][CH3:25])=[O:23])[CH:15]=[CH:16][CH:17]=1)[CH2:3][CH2:4][NH:5][C:6](=[O:11])[C:7]([F:10])([F:9])[F:8]>CCO>[OH:1][CH:2]([C:12]1[CH:13]=[C:14]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]([NH:24][CH3:25])=[O:23])[CH:15]=[CH:16][CH:17]=1)[CH2:3][CH2:4][NH:5][C:6](=[O:11])[C:7]([F:10])([F:9])[F:8]

Participants

3

Reactant 1

HCID 86635861HCID 86635861, compound

Product 1

HCID 86635860HCID 86635860, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reduction of 5-(3-(1-hydroxy-3-(2,2,2-trifluoro acetamido) propyl)phenyl)-N-methylpent-4-ynamide using EtOH as the solvent yielded 5-(3-(1-hydroxy-3-(2,2,2-trifluoro acetamido)propyl)phenyl)-N-methyl pentanamide as yellow oil. Yield (0.911 mg, 83%). 1H NMR (400 MHz, CDCl3) δ 8.0 (bs, 1H), 7.27 (t, J=7.2 Hz, 1H), 7.16 (s, 1H), 7.14 (d, J=7.6 Hz, 1H), 7.10 (d, J=7.6 Hz, 1H), 5.56 (bs, 1H), 4.83-4.86 (m, 1H), 3.54-3.60 (m, 1H), 3.37-3.44 (m, 1H), 2.76 (d, J=4.8 Hz, 3H), 2.63 (t, J=7.6 Hz, 2H), 2.12 (t, J=7.6 Hz, 2H), 1.96-2.0 (m, 2H), 1.58-1.67 (m, 4H).

Sources & evidence

ORD record
ord-0b239c4b78a2407abab68f7c7158aa60
Source dataset
uspto-grants-2011_12
Patent number
US08076516B2

Reaction notes

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