HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 3-{2-[(tert-Butoxycarbonyl)amino]ethoxy}benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 18930691 | HCID 18930691 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-{2-[(tert-Butoxycarbonyl)amino]ethoxy}benzoic acid | HCID 22397457 | — |
Reaction Steps
Hydrolysis of methyl 3-(2-(tert-butoxycarbonylamino)ethoxy)benzoate following the method used in Example 9 except that LiOH and THF were used instead of K2CO3 and MeOH gave 3-(2-(tert-butoxycarbonylamino)ethoxy)benzoic acid that was used directly in next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076516B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-561d48fc556244bab13613262de3ec81 |
| Source note | uspto-grants-2011_12 |