HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethynylheptan-4-ol → Tert-butyl 3-fluoro-3-(3-(3-hydroxy-3-propylhex-1-ynyl)phenyl)propylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethynylheptan-4-ol | HCID 12383898 | — |
| Reactant | Tert-butyl 3-(3-bromophenyl)-3-fluoropropylcarbamate | HCID 66743475 | — |
| Product | Tert-butyl 3-fluoro-3-(3-(3-hydroxy-3-propylhex-1-ynyl)phenyl)propylcarbamate | HCID 66743011 | — |
Reaction Steps
Sonogashira coupling of tert-butyl 3-(3-bromophenyl)-3-fluoropropylcarbamate and 4-ethynylheptan-4-ol following the method described in Example 12 gives tert-butyl 3-fluoro-3-(3-(3-hydroxy-3-propylhex-1-ynyl)phenyl)propylcarbamate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076516B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-51dcbacd58814200b250dc29d36f23e9 |
| Source note | uspto-grants-2011_12 |