Lawesson's reagent → HCID 75293380, compound

Participants

Reaction Steps

A mixture of racemic (2′S, 3S, 4′R)-6-chloro-4′-[5-chloro-2-(1-methoxycarbonyl-1-methyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl) spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (200 mg, 0.34 mmol) prepared in Example 5 and Lawesson's Reagent (270 mg, 0.61 mmol) in THF (5 mL) was stirred at room temperature for 1 h, then purified by flash column chromatography to give the title compound as white solid (130 mg).

Provenance & Evidence